Accessibility Links
  • Job reference: RMS0165712

Senior Scientist - MCC Upstream Process Dev Lead

  • Sector: Engineering
  • Location: Billingham
  • Job type: Permanent
  • Date posted: 02/08/2016
  • Time left:
    d h m s
This vacancy has now expired.
Send jobs like this to my email
The Company:
One of the world's leading private biotechnology companies, developing and manufacturing innovative biotechnology-based medicines for human healthcare products, with a focus on microbial-derived biologics .

The Role:
An accomplished technical leader who can demonstrate a strong track record for the successful development, optimisation, characterisation and transfer to cGMP manufacturing of state-of-the-art mammalian upstream manufacturing processes – applies extensive scientific and technical experience and business acumen to drive high-quality laboratory work, and deliver well-controlled and characterised upstream manufacturing processes to aggressive timelines. Projects will range from early phase to commercial stage biologics.

Provide leadership and direction to the process development sub-group within Mammalian Cell Culture R&D, a group of 3-15 scientists.

Technical Skills Requirements

• Design, develop and scale up reproducible and robust cGMP compliant mammalian cell culture upstream processes.

• Provide strong scientific and technical leadership in the application of Design of Experiments (DoE) and appropriate cell culture scale down models.

o Experience in: media / feed screening, development, and optimisation; feed strategy; process parameter optimisation; etc.

• Support transfer of existing upstream processes from customers and facilitate process development for / transfer to cGMP manufacturing.

• Have knowledge and experience with glass, stainless steel and single use fed-batch culture processes, at different scales and with different control systems, for recombinant protein production.

• Write and revise protocols, procedures, reports and other process related documentation as necessary to support upstream process development and transfer to cGMP manufacturing operations.

• Provide strong scientific and technical leadership in the identification, evaluation, and championing of new technologies for upstream process development whilst maintaining and improving established technologies.

• Demonstrate current knowledge of industry trends, practices and standards.

• Having knowledge and understanding of process characterisation and QbD principles, and of FMEA, is a plus.

Essential Skills / Qualifications:
Ideally a PhD degree in Biochemical Engineering, Biotechnology, Cell Biology, or related field.

10+ years experience in the biotech/pharmaceutical industry within a mammalian cell culture role and an excellent understanding of the theory and practice of cell culture and process development is required.

Documented solid history of technical accomplishments in the mammalian cell culture field, e.g. relevant experience in upstream process development.

Desirable Skills / Qualifications:
Experience working in a CMO environment would be a benefit, but not essential.
Similar jobs
Tim Williams
Gateline Customer Service Assistant Location Birmingham, West Midlands Duration ongoing The Role: Our client is a train service operator who are...
Scott Webb
Afloat Services Engineer Location Middlesbrough, North Yorkshire Duration staff The Role: The Afloat Services Engineer is responsible for...
Andrew Pritchard
Field Service Engineer (marine) Location Aberdeen Duration staff The Role: Role Outline You will be required to perform the...

Back to Top